Outcomes of Keratorefractive Lenticule Extraction in Older Adults: A Multicenter Analysis

Evidence database / Studies / neuhann-2026-klex-older-adults

—enrolled patients*

288enrolled eyes*

2structured arms

—maximum standardized days follow-up

* Descriptive sum of reported arm counts. “≥” indicates that one or more arm counts were not reported; missing values are not treated as zero.

Study arm

Age 55 or older

SMILE

Population

Patients: Not reported
Eyes: 144
Bilateral treatment: Not reported
Age range: Not reported
Sphere range: Not reported
Cylinder range: Not reported
Spherical equivalent: Not reported
Corneal thickness: Not reported

Eligibility definition

Inclusion
Myopia or myopic astigmatism; age at least 55 years.

Exclusion
Not structured

Reported outcomes by follow-up

Outcome	Follow-up	Follow-up sample	Result	Reported fraction	Provenance
Uncorrected distance acuity 20/20 or better efficacy	Postoperative assessment (timing not specified in abstract)	—	79.0%	Not reported	VERIFIED Source · Abstract
Mean uncorrected distance acuity efficacy	Postoperative assessment (timing not specified in abstract)	—	-0.010 logMAR	Not reported	VERIFIED Source · Abstract
Spherical equivalent within ±0.50 D predictability	Postoperative assessment (timing not specified in abstract)	—	76.0%	Not reported	VERIFIED Source · Abstract
Re-treatment rate refractive	Postoperative assessment (timing not specified in abstract)	—	9.0%	Not reported	VERIFIED Source · Abstract

Complications

No structured complication observations are available for this arm. This means “not reported in this dataset,” not zero complications.

Study arm

Age 35 or younger

SMILE

Population

Patients: Not reported
Eyes: 144
Bilateral treatment: Not reported
Age range: Not reported
Sphere range: Not reported
Cylinder range: Not reported
Spherical equivalent: Not reported
Corneal thickness: Not reported

Eligibility definition

Inclusion
Myopia or myopic astigmatism; age 35 years or younger; matched by preoperative MRSE.

Exclusion
Not structured

Reported outcomes by follow-up

Outcome	Follow-up	Follow-up sample	Result	Reported fraction	Provenance
Uncorrected distance acuity 20/20 or better efficacy	Postoperative assessment (timing not specified in abstract)	—	93.0%	Not reported	VERIFIED Source · Abstract
Mean uncorrected distance acuity efficacy	Postoperative assessment (timing not specified in abstract)	—	-0.070 logMAR	Not reported	VERIFIED Source · Abstract
Spherical equivalent within ±0.50 D predictability	Postoperative assessment (timing not specified in abstract)	—	88.0%	Not reported	VERIFIED Source · Abstract
Re-treatment rate refractive	Postoperative assessment (timing not specified in abstract)	—	1.0%	Not reported	VERIFIED Source · Abstract

Complications

No structured complication observations are available for this arm. This means “not reported in this dataset,” not zero complications.

Study design

Retrospective multicenter age-group comparison matched by preoperative MRSE.

Country: Not reported
Publication-reported places: Munich, Germany · Trier, Germany · Marburg, Germany · Luxembourg, Luxembourg · Linz, Austria
Multicenter: Yes
Prospective: No
Randomized: No
Source type: RETROSPECTIVE
Regulator: Not reported

Place metadata may refer to a treatment site, institution or author affiliation. Confirm its role in the linked publication.

Limitations and notes

Abstract-reviewed: 288 eyes from 183 patients overall; 144 eyes in each age group. Per-group patient counts, full age ranges, and follow-up timing are not reported in the abstract. Partial age bounds are eligibility thresholds. KLEx is indexed under the existing lenticule-extraction category; the device model is not assumed. Some authors report relationships with device manufacturers.

Missing fields are not interpreted as negative findings. Arm counts may not be additive in all study designs.

Study evidence level
A simple, non-GRADE hierarchy based on design: randomized and large regulatory trials are high; prospective cohorts moderate; retrospective observational studies low. Manual review can override this label.