Effects of SMILE on intraocular pressure and corneal biomechanics: a systematic review and meta-analysis

Evidence database / Studies / lampsas-2026-smile-iop-meta-analysis

—enrolled patients*

1,177enrolled eyes*

1structured arms

—maximum standardized days follow-up

* Descriptive sum of reported arm counts. “≥” indicates that one or more arm counts were not reported; missing values are not treated as zero.

Study arm

SMILE pooled observational evidence

SMILE

Population

Patients: Not reported
Eyes: 1177
Bilateral treatment: Not reported
Age range: Not reported
Sphere range: Not reported
Cylinder range: Not reported
Spherical equivalent: Not reported
Corneal thickness: Not reported

Eligibility definition

Inclusion
Observational studies reporting preoperative and postoperative IOP after SMILE using GAT, ORA, or Corvis ST.

Exclusion
Not structured

Reported outcomes by follow-up

Outcome	Follow-up	Follow-up sample	Result	Reported fraction	Provenance
Measured IOP reduction with GAT safety	Pooled postoperative follow-up	1177 eyes	3.47	Not reported	VERIFIED Source · Abstract
Measured IOP reduction with ORA safety	Pooled postoperative follow-up	1177 eyes	2.50	Not reported	VERIFIED Source · Abstract
Measured IOP reduction with Corvis ST safety	Pooled postoperative follow-up	1177 eyes	1.52	Not reported	VERIFIED Source · Abstract

Complications

No structured complication observations are available for this arm. This means “not reported in this dataset,” not zero complications.

Study design

Systematic review and meta-analysis of 17 observational studies reporting preoperative and postoperative intraocular-pressure measurements after SMILE.

Country: Not reported
Publication-reported places: Not reported
Multicenter: Yes
Prospective: Not reported
Randomized: Not reported
Source type: META ANALYSIS
Regulator: Not reported

Place metadata may refer to a treatment site, institution or author affiliation. Confirm its role in the linked publication.

Limitations and notes

The measured postoperative IOP reductions reflect measurement underestimation and corneal biomechanical change, not necessarily a true reduction in physiologic IOP.

Missing fields are not interpreted as negative findings. Arm counts may not be additive in all study designs.

Study evidence level
A simple, non-GRADE hierarchy based on design: randomized and large regulatory trials are high; prospective cohorts moderate; retrospective observational studies low. Manual review can override this label.